Computational Biology and Biomolecular NMR Spectroscopy
Robert Konrat
Group Leader
robert.konrat@univie.ac.at
Phone: +43-1-4277-52202
Campus Vienna Biocenter 5, 1030 Vienna | Room: 1.602
Research
Research
The sequencing of the human genome has provided a ‘parts list’ of the human inventory comprising potential therapeutic targets for the pharmaceutical and biotechnology industry. In order to cope with this huge number of targets we introduced a new theoretical conception of protein structural biology (meta-structure) that can be used for protein sequence-to-function annotation and drug design. A hallmark of our research is the integrative application of this novel conception and sophisticated NMR spectroscopy directed towards a better understanding of fundamental biological processes. Finally, as much of protein function is predicated on dynamics, we are developing novel methodological approaches that combine biochemistry, bioorganic chemistry and NMR spectroscopy to unravel the microscopic details of functionally important protein plasticity.
Publications
Henen, Morkos A; Coudevylle, Nicolas; Geist, Leonhard; Konrat, Robert (2012). Toward Rational Fragment-Based Lead Design without 3D Structures. J MED CHEM;55(17):7909-19. PMID: 22889313
Brüschweiler, Sven; Konrat, Robert; Tollinger, Martin (2013). Allosteric Communication in the KIX Domain Proceeds through Dynamic Repacking of the Hydrophobic Core. ACS chemical biology;8(7):1600-10. PMID: 23651431
Kurzbach, Dennis; Schwarz, Thomas C; Platzer, Gerald; Höfler, Simone; Hinderberger, Dariush; Konrat, Robert (2014). Compensatory adaptations of structural dynamics in an intrinsically disordered protein complex. ANGEW CHEM INT EDIT;53(15):3840-3. PMID: 24604825
more publications of the group Konrat
Christian Doppler Laboratory for knowledge-based structural biology and biotechnology
Project-leader: Kristina Djinović-Carugo and Robert Konrat
Business partner: Boehringer Ingelheim RCV GmbH & Co KG, Arsanis Biosciences GmbH and Biomin Holding GmbH
Duration: 01.02.2017 - 31.01.2024
CD Laboratory for knowledge-based structural biology and biotechnology
Christian Doppler Research Association
University of Vienna
Description: The scientists will primarily investigate protein structure, which is crucial for the development of new therapeutic methods for a great variety of diseases ranging from Alzheimer’s and infectious diseases to cancer. This renders it a most valuable tool in biomedical research. In order to gain new insights into protein structure, function and interactions that could potentially be translated into new therapies, the researchers will employ a combination of bioinformatics, protein production and high-end biophysical and structural biology techniques. The collected information will ultimately be combined in an information pipeline for both research and biotechnology.
Doctoral Program "Integrative Structural Biology"
2016-2019: The Group Konrat participates in the special Doctoral Program "Integrative Structural Biology" reviewed and funded by the Austrian Science Fund FWF.
Doctoral Program "Structure and Interaction of Biological Macromolecules"
The Group Konrat participates in the special Doctoral Program "Structure and Interaction of Biological Macromolecules" reviewed and funded by the Austrian Science Fund FWF.